Noblastic T-cell lymphoma; PTCL-NOS ?peripheral T-cell lymphoma not otherwise specified; ATLL – adult T-cell leukemia/lymphoma; M ?male; F ?female; LN – lymph node; TRG@ – T-cell receptor chain rearrangement; IG@ – immunoglobulin gene rearrangement; c ?clonal; computer ?polyclonal; NOS- not otherwise specified#6 situations more than 1 location4 cases more than one particular locationAm J Surg Pathol. Author manuscript; available in PMC 2014 June 01.*not all the circumstances had been analyzed for TRG@ and IG@ by PCRNIH-PA Author ManuscriptPageNIH-PA Author ManuscriptNIH-PA Author ManuscriptTableClinical capabilities of patients with T-cell lymphoma and HRS-like cells, EBV negativeClinical presentation and Treatment Presented with skin rash, fat loss, generalized lymphadenopathy, splenomegaly Treated with 2xABVD, 4x DAEPOCH, autologous bone marrow transplant Presented with respiratory insufficiency, mediastinal and supraclavicular lymphadenopathy Presented with cervical and paraaortic lymphadenopathy; no other clinical information readily available Presented with cervical lymphadenopathy, no constitutional symptoms, no hepatosplenomegaly. Patient has declined therapy. Presented with skin rash, inguinal and axillary lymphadenopathy, no hepatosplenomegaly, diagnosed and treated as CHL (8xABVD); LN recurrence at two years treated 2xCOPP and inguinal radiation; skin/soft tissue forearm and LN recurrence 7 years later recognized as PTCL. PTCLNOS, follicular variant IV Inguinal LNs and skin AWD PTCLNOS, follicular variant IV Cervical LN AWD (12 months) AITL# Not identified Cervical LN Not recognized AITL Not recognized Supraclavicular Not recognized AITL IV Inguinal LN AWoD, 3 months following transplant Diagnosis Stage Biopsy Web-site(s) Outcome (months)Nicolae et al.1316852-65-9 In stock Case noAge (yr)/ Sex65/M75/F83/F51/M67/MAm J Surg Pathol.Histamine web Author manuscript; out there in PMC 2014 June 01.#Case three also showed some capabilities of PTCL, NOS, follicular variant. Abbreviations: HRS ?Hodgkin/Reed- Sternberg; EBV ?Ebstein-Barr Virus; M – male; F ?female; AITL ?angioimmunoblastic T-cell lymphoma; PTCL-NOS ?peripheral T-cell lymphoma not otherwise specified; CHL ?classical Hodgkin’s lymphoma; LN ?lymph node; AWoD, alive with out disease; AWD, alive with disease; ABVD, doxorubicin, bleomycin, vinblastine and dacarbazine; DA-EPOCH, dose-adjusted etoposide, prednisone, oncovin, cyclophosphamide and hydroxydaunorubicin; COPP – cyclophosphamide, oncovin, procarbazine, prednisoneNIH-PA Author ManuscriptPageNIH-PA Author ManuscriptNIH-PA Author ManuscriptTableImmunophenotype of neoplastic T cell and HRS-like cells within the 5 EBV-negative T-cell lymphomas (instances 1, two, 3 – AITL; instances 4, five – PTCL-NOS, follicular variant).PMID:35116795 Neoplastic T-cell phenotype Case 2 + cp, r +r +r +f +f Expanded FDC Expanded FDC Residual FDC Residual FDC + +f + +f + f, r +r +r + +r +r + w, r +r +r + +f +f + +f + + + + + + f, w + f, w + f, w +s + f, w +f + f, w +v +v +v +w +w +v +v +v +v +v Case 3# Case 4 Case five Case 1 Case two Case 4 Case five Case 3# HRS-like cell phenotypeCaseCD-PAX-Oct–CD79a-Kappa-Lambda-CD+fCD-CD+rCD+rCD-PD-+rCD+ f, rBcl-+ f, rMUM-Am J Surg Pathol. Author manuscript; obtainable in PMC 2014 June 01.LMP-CDExpanded FDCAbbreviations: HRS ?Hodgkin/Reed-Sternberg; EBV ?Ebstein-Barr Virus; AITL ?angioimmunoblastic T-cell lymphoma; PTCL-NOS ?peripheral T-cell lymphoma not otherwise specified; FDC ?follicular dendritic cells; s- powerful, w ?weak, v ?variable intensity, f ?focal, r ?rosettes, cp ?cytoplasmic.#Case three also showed some capabilities of PTCL, NOS, follicular variant.NIH-PA.